Self-selection for mammography screening according to use of hormone replacement therapy: A systematic literature review

Mammography screening participation may be influenced by the awareness of an increase in breast cancer risk due to hormone replacement therapy (HRT), which received particular attention upon publication Women’s Health Initiative (WHI) trial results 2002. Our aim was synthesize evidence on a potential self-selection for mammography according HRT use. We systematically searched literature (MEDLINE, EMBASE, CINAHL) studies reporting association between use and participation. Data were extracted independently two reviewers. Overall, 2018 identified. Of these, 32 from nine countries, predominantly North America (50%) Europe (28%), included. In all countries 94% studies, higher uptake among users compared non-users reported. 21 odds ratio, positive, about 70% these this ≥ 2. This also held true exclusively using data collected before WHI findings 2002 (63% studies). The not restricted certain types (organized vs. opportunistic) or (combined estrogen-only). found consistent relevant is considerable relevance design interpretation investigating factors evaluating preventive measures cancer. • first systematic review summarizing association. Included (n=32, 9 countries) provided information 1,945,044 women. Studies used 1988 2014 2002). Screening (all total).